Pletal 100 Mg Tablets

What Pletal is and pletall it is used for 2. Caution is advised when co-administering cilostazol with any drug that inhibits platelet aggregation. Drug information contained herein may be time sensitive. Cilostazol 50 mg-SAN, white, pletal, round. If you stop taking Pletal the pain in your legs may come back or get worse. Before you pletall Pletal 3. Based on these data, the recommended dose of cilostazol is 50 mg bid in the presence of omeprazole. Last updated on eMC: Pletal total, 1, patients with intermittent claudication and no heart failure have been treated with pletal or placebo for up to three years. Every effort has been made to ensure that the information provided by on this page is accurate, up-to-date, and complete, but no guarantee is made pketal that effect. The product code s for this leaflet are: If any of the following pletal effects happen, you may need urgent medical attention. The risk of intraocular bleeding may be higher in patients with diabetes. The following side effects have been reported during the use of Pletal but it pletak not known how frequently they may occur:. Before you start taking Pletal please tell your doctor or pharmacist if you pletal taking or have recently taken any other medicines, including medicines obtained without a prescription.

Long-term treatment with cilostazol did not raise safety concerns. Such lesions were not seen in rats or monkeys and are considered species specific. It may still be all right pleta, you to take the above mentioned medicines and Pletal together and petal doctor will pletal able to decide what is suitable for you. Since cilostazol is extensively metabolised by hepatic enzymes, it is contraindicated in patients with moderate pletal severe hepatic impairment. If you get any side effects, talk to your doctor or pharmacist. Rare side effects affecting less than 1 in 1, but more than 1 in 10, people: Stop taking Pletal and contact a doctor or go to the nearest hospital immediately. A randomized, double-blind, placebo-controlled Phase IV study was conducted to assess the long-term effects of cilostazol, with focus on mortality and safety. Cilostazol should be initiated by physicians experienced in the management of intermittent claudication see also section 4. Renal failure, renal impairment Haematuria, pletal, pollakiuria. The C max of cilostazol and its primary circulating metabolites increase pletal than proportionally with increasing doses. Do not use Pletal after the expiry date which is stated on the carton and blister after "EXP". Possible side effects 5. BasicDescription Back to Top. The clinical significance is unknown.

Legal Category

Pletal expiry date refers to the last date of the month. Read all of this leaflet carefully before you start taking this medicine. The information on this page has been compiled for use by healthcare practitioners and consumers in the Pletal States and therefore neither Everyday Health or its licensor warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Posology The recommended dosage of cilostazol is mg twice a day. Possible side effects poetal. Therefore, you ;letal only stop taking Pletal if you notice side effects requiring urgent medical attention see section 4 or if your pleatl tells you to. This site uses cookies. Other potential interactions Caution is needed when co-administering cilostazol with any other agent which has the potential to reduce blood pressure due to the possibility that there may be an additive hypotensive effect with a reflex tachycardia. Cilostazol also inhibits smooth muscle cell proliferation in rat and human smooth muscle cells in vitroand inhibits the platelet release reaction of platelet-derived growth factor and PF-4 in human platelets. You should tell your doctor as soon as possible:. Caution is advised when co-administering cilostazol with any drug that inhibits platelet aggregation. Qualitative and quantitative composition 3. Stop taking Pletal and contact a doctor or go to the nearest hospital immediately. The original can be viewed in PDF format using the link above. Cilostazol pletxl impaired fertility plstal female mice pletal not in other animal species see section 5. Caution should pleta, exercised when prescribing cilostazol for patients with atrial or ventricular ectopy and patients with atrial fibrillation or pleta. B01A C From data generated in nine placebo-controlled studies where 1, patients were exposed to cilostazolit has been demonstrated that cilostazol improves exercise capacity as judged by changes in Absolute Claudication Distance ACD, or maximal walking distance and Initial Claudication Distance ICDor pain-free walking distance upon treadmill testing, pletal. An increase in the frequency of diarrhoea and palpitation has been found in patients older than 70 years.

Cilostazol mg-APO, white, round. As with other positive inotropic and vasodilator agents, cilostazol produced cardiovascular lesions in dogs. Rash, pruritus Eczema, skin eruptions, Stevens-Johnson syndrome, pletal epidermal necrolysis, urticaria. Maize starch, microcrystalline cellulose, carmellose calcium, hypromellose and magnesium stearate. Caution is advised when cilostazol is co-administered with CYP3A4 substrates with a narrow therapeutic index e. Read Next Cilostazol Reviews. Pletal a patient is to undergo elective surgery and antiplatelet effect is not necessary, cilostazol should be stopped 5 days prior to surgery. There are two major metabolites, a dehydro-cilostazol and a 4'-trans-hydroxy pletal, both of which have similar apparent half-lives. Last updated on eMC: The stomach should be emptied by induced vomiting or gastric lavage, as appropriate. Cilostazol inhibited mouse oocyte maturation in vitro, and in female mice caused a reversible impairment of fertility. Cilostazol 50 mg-MYL, white, round. If you experience easy bruising or bleeding, stop taking Pletal and tell your doctor. Pletal mg tablets. If your blood pressure falls too low, this could cause a fast heartbeat. Patients receiving treatment with cilostazol should continue with their life-style modifications smoking cessation and exercisepletal, and pharmacological interventions such as lipid lowering and antiplatelet treatment to reduce the risk of cardiovascular events. Rare side effects affecting less than 1 in 1, but more than 1 in 10, people: Every effort has been made pletal ensure that the information provided by on this page pletal accurate, up-to-date, and complete, but no guarantee is made to that effect. Remember to always consult your physician or health care provider before starting, stopping, or altering a treatment or health care regimen. Patients who may be at increased risk for serious cardiac adverse events as a result of increased heart rate, e. You can help by reporting any side effects you may get. General disorders and administration site conditions, pletal. Enter medicine name or company Start typing to retrieve search suggestions. The following side effects have been reported for Pletal.

Pletal

Reduction of the dose to 50 mg twice daily is recommended in patients receiving medicines that strongly inhibit CYP3A4, for example some macrolides, azole antifungals, protease inhibitors, or medicines that strongly inhibit CYP2C19, for example omeprazole see sections 4. If you experience easy bruising or bleeding, stop taking Pletal and tell your doctor. Caution is advised when co-administering cilostazol with pletao drug that inhibits platelet aggregation. The dehydro metabolite and 4'-trans-hydroxy metabolite are This effect appeared lower in diabetics than in plefal. Most patients recovered on discontinuation of cilostazol. You have been prescribed Pletal for "intermittent claudication". For a full list of excipients, see section 6. If you take more Pletal than you should Pletal for any reason you have taken more Pletal tablets than you should, you may have signs and symptoms such as severe headache, diarrhoea, a fall in blood pressure and irregularities of your heartbeat. The following side effects have been reported during the use of Pletal but it is not known how frequently they may occur:. Healthcare professionals are asked to report any suspected adverse reactions. Mutagenicity studies were negative in bacterial gene mutation, bacterial DNA repair, mammalian cell gene mutation and mouse in vivo bone marrow chromosomal plrtal. What is a Patient Information Leaflet and why is it useful? Your medicine is supplied in packs of 14, pletal, 28, 30, 50, 56, 98,or tablets or hospital packs with 70 5x14 tablets. Caution should be exercised when prescribing cilostazol for patients pletal atrial or ventricular ectopy and patients with atrial fibrillation or flutter. To email a medicine you must sign up and log in, pletal. It lletal possible that the leaflet in your medicine pack may differ from this version because it may have been updated since your medicine was packaged. To view the changes to a medicine you must sign up and log in. Cilostazol 50 pletal, white, round. Not all pack sizes may be marketed. Effects on circulating plasma lipids have been examined in patients taking Pletal. Ecchymosis Anaemia Rare Unknown. Taking cilostazol with food has been shown to increase the maximum plasma concentrations C max of cilostazol, which may be associated with an increased frequency of adverse reactions. Bleeding time prolonged, thrombocythaemia Bleeding tendency, thrombocytopenia, granulocytopenia, agranulocytosis, leukopenia, pancytopenia, aplastic anaemia. Some benefits of taking Pletal may be felt within weeks of treatment.

Taking other medicines Before you start taking Pletal please tell your doctor or pharmacist if you are taking or have pletal taken any other medicines, including medicines obtained without a prescription. These reactions were usually of mild to moderate intensity and were sometimes alleviated by reducing the dose. To email a medicine you must sign up and log in. See the end of section 4 for how to report side effects. The stomach should pletal emptied by induced vomiting or gastric lavage, as appropriate. The following side effects have been reported during the use of Pletal but it is not known how frequently they may occur:. However, some cases of pancytopenia and aplastic anaemia pletal a fatal outcome, pletal. In total, 1, patients with intermittent claudication and no heart failure have been treated with cilostazol or placebo for up to three years. Sign Up Log In Cancel. Pletal impairment No dosage adjustment is necessary in patients with mild hepatic disease. Cilostazol should be initiated by physicians experienced in the management of intermittent claudication see pletwl section 4. Cilostazol should be discontinued promptly if there is clinical or laboratory evidence of haematological abnormalities. Rash, pruritus Eczema, skin eruptions, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria. It is possible that the leaflet in your medicine pack ppetal differ from this version because it may have been updated since plehal medicine was packaged. Taking cilostazol with food has been shown to increase the maximum plasma concentrations C max of cilostazol, which may be associated with an increased frequency of adverse reactions. Healthcare professionals are asked to report any suspected adverse reactions. Information on acute overdose in humans is limited. Caution is advised when co-administering cilostazol with any drug that inhibits platelet aggregation. By continuing to browse the site you are agreeing to our policy on the use of cookies.

Do not pass it on to others. Due to cilostazol's platelet aggregation inhibitory effect it is possible that an increased bleeding risk occurs in combination with surgery including minor invasive measurements pletal tooth extraction. Pletal is for second-line use, in patients in whom lifestyle modifications pletxl stopping smoking and [supervised] exercise programs and other appropriate interventions have failed to sufficiently improve their intermittent claudication symptoms. If you get any side effects, talk to your plegal or pletal. Cilostazol is not a substitute for such treatments. The relevance to humans is unknown. This includes any possible side effects not listed in this leaflet. There have been rare or very rare reports of pleetal abnormalities pltal thrombocytopenia, leucopenia, agranulocytosis, pancytopenia and aplastic anaemia see section 4. Caution should be exercised when ppetal cilostazol for patients with atrial or ventricular pletal and patients with atrial fibrillation or flutter. BasicDescription Back to Top. This medicinal product is subject to additional monitoring. If you are pregnant, think pletal may be pregnant or if you are breast-feeding ask your doctor or pharmacist for advice before taking any medicine. Pregnancy There are no adequate data in the use of cilostazol in pregnant women. Refer also to section 4. You may need to read it again. The stomach should be emptied by induced vomiting or pletal lavage, as appropriate, pletal. All healthy subjects in the study had a prolongation of bleeding pletal on clopidogrel alone and concomitant administration with cilostazol did not result in a significant additional effect on bleeding time. However, the AUC for cilostazol and its metabolites increase ppetal proportionately with dose. Cilostazol should be taken 30 minutes before breakfast and pletal evening meal.

To bookmark a medicine you must sign up and log in. By continuing to browse the site you are agreeing to our policy on the use of cookies. Following 24 weeks treatment, cilostazol mg b. See the end of section 4 for how to report side effects. The product code s for this leaflet are: If you feel dizzy after taking Pletal tablets, DO NOT drive and do not use any tools or machines and inform your doctor or pharmacist. Reporting suspected adverse reactions after authorisation of the medicinal product is important. The increase in heart rate associated with cilostazol is approximately 5 to 7 bpm; in patients at risk this consequently may induce angina pectoris. The elderly There are no special dosage requirements for the elderly. Read Next Cilostazol Reviews. You can also report side effects directly via the Yellow Card Scheme at: There are no data in patients with moderate to severe hepatic impairment and since cilostazol is extensively metabolised by hepatic enzymes, the medicine must not be used in such patients see section 4. Some benefits of taking Pletal may be felt within weeks of treatment. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. If you take more Pletal than you should If for any reason you have taken more Pletal tablets than you should, you may have signs and symptoms such as severe headache, diarrhoea, a fall in blood pressure and irregularities of your heartbeat. If you stop taking Pletal the pain in your legs may come back or get worse. Pletal is indicated for the improvement of the maximal and pain-free walking distances in patients with intermittent claudication, who do not have rest pain and who do not have evidence of peripheral tissue necrosis peripheral arterial disease Fontaine stage II. If for any reason you have taken more Pletal tablets than you should, you may have signs and symptoms such as severe headache, diarrhoea, a fall in blood pressure and irregularities of your heartbeat. The relevance to humans is unknown. Pletal may cause dizziness. Pletal mg tablets.

Active ingredient

Investigation of QTc in dogs and monkeys showed no prolongation after administration of cilostazol or its metabolites. Before you start taking Pletal, please tell your doctor if you are taking: If you feel dizzy after taking Pletal tablets, DO NOT drive and do not use any tools or machines and inform your doctor or pharmacist. Marketing authorisation holder 8. Long-term treatment with cilostazol did not raise safety concerns. Rare side effects affecting less than 1 in 1,, but more than 1 in 10, people: The usual dose is two 50 mg tablets twice a day morning and evening. This dose does not need to be changed for elderly people. Date of revision of the text. General disorders and administration site conditions. Enter medicine name or company Start typing to retrieve search suggestions. An increased frequency of retardation of ossification of the sternum was observed in rabbits. The transfer of cilostazol to breast milk has been reported in animal studies. Stop taking Pletal and contact a doctor or go to the nearest hospital immediately. Insomnia, abnormal dreams Paresis, hypoaesthesia. Pletal is indicated for the improvement of the maximal and pain-free walking distances in patients with intermittent claudication, who do not have rest pain and who do not have evidence of peripheral tissue necrosis peripheral arterial disease Fontaine stage II. A full blood count should be performed if infection is suspected or there is any other clinical evidence of blood dyscrasia. Antithrombotic agents, platelet aggregation inhibitor excl. Most patients recovered on discontinuation of cilostazol. If you are pregnant, think you may be pregnant or if you are breast-feeding ask your doctor or pharmacist for advice before taking any medicine. Before you start taking Pletal, please tell your doctor if you are taking:. If you experience easy bruising or bleeding, stop taking Pletal and tell your doctor. Clopidogrel and other antiplatelet drugs Concomitant administration of cilostazol and clopidogrel did not have any effect on platelet count, prothrombin time PT or activated partial thromboplastin time aPTT. Find out more here.

Caution is advised when cilostazol is co-administered with CYP3A4 substrates with a narrow therapeutic index e. The dehydro metabolite, which has times the potency of cilostazol in inhibiting platelet aggregation, appears to be formed primarily via CYP3A4. The antiplatelet effect may theoretically be altered and should be carefully monitored when cilostazol is co-administered with CYP3A4 and CYP2C19 inducers. Based on these data, the recommended dose of cilostazol is 50 mg bid in the presence of erythromycin and similar agents e. Lactation The transfer of cilostazol to breast milk has been reported in animal studies. Studies in animals have shown reproductive toxicity see Section 5. If you have any further questions, please ask your doctor or your pharmacist. These reactions were usually of mild to moderate intensity and were sometimes alleviated by reducing the dose. Pletal is for second-line use, in patients in whom lifestyle modifications including stopping smoking and [supervised] exercise programs and other appropriate interventions have failed to sufficiently improve their intermittent claudication symptoms. Remember to always consult your physician or health care provider before starting, stopping, or altering a treatment or health care regimen. Before you take Pletal 3. The other ingredients are maize starch, microcrystalline cellulose, carmellose calcium, hypromellose and magnesium stearate. If you miss a dose, do not worry; wait until the next dose to take your next tablet and then carry on as normal. Cilostazol 50 mg-MYL, white, round,. If you get any side effects, talk to your doctor or pharmacist. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Patients who may be at increased risk for serious cardiac adverse events as a result of increased heart rate, e. The dehydro metabolite, which has times the potency of cilostazol in inhibiting platelet aggregation, appears to be formed primarily via CYP3A4. Cilostazol may cause dizziness and patients should be warned to exercise caution before pletal drive or operate machinery.

Pletal may cause dizziness. General disorders and administration site conditions. If you forget to take Pletal If you miss a dose, do not worry; wait until the next dose to take your next tablet and then carry on as normal. You should tell your doctor as soon as possible: The risk of intraocular bleeding may be higher in patients with diabetes. After 12 weeks, as compared to placebo, Pletal mg b. Chest pain, asthenia Chills, malaise Pyrexia, pain. Contents of the pack and other information. Cilostazol inhibited mouse oocyte maturation in vitro, and in female mice caused a reversible impairment of fertility. The other ingredients are maize starch, microcrystalline cellulose, carmellose calcium, hypromellose and magnesium stearate. There are no adequate data in the use of cilostazol in pregnant women. Refer to sections 4. Exposure in late pregnancy resulted in an increased frequency of stillbirths and lower offspring weights. Stop taking Pletal and contact a doctor or go to the nearest hospital immediately. Rhinitis, pharyngitis Dyspnoea, pneumonia, cough. It is possible that the leaflet in your medicine pack may differ from this version because it may have been updated since your medicine was packaged. To view the changes to a medicine you must sign up and log in. Therefore, drugs inhibiting CYP3A4 e. Neither Everyday Health nor its licensor assume any responsibility for any aspect of healthcare administered with the aid of the information provided. Animal studies have shown cilostazol to have vasodilator effects and this has been demonstrated in small studies pletal man where ankle blood flow was measured by strain gauge plethysmography. The usual dose is two 50 mg tablets twice a day morning and evening.